Description

Methyl 1-Cbz-3-Methylpyrrolidine-3-Carboxylate CAS NO 912444-74-7 is a high-purity, protected pyrrolidine derivative used as a critical chiral building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures, offering a versatile scaffold for the introduction of the 3-methylpyrrolidine moiety. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Peptidomimetic Synthesis: Serves as a constrained proline analog for the design and synthesis of peptidomimetics to enhance metabolic stability and bioavailability.
• Agrochemical Research: Used as a building block in the discovery of new pesticides and herbicides with specific stereochemical requirements.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	Methyl 1-Cbz-3-Methylpyrrolidine-3-Carboxylate
CAS No.	912444-74-7
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	Methyl 1-[(benzyloxy)carbonyl]-3-methylpyrrolidine-3-carboxylate; 1-Cbz-3-Methylpyrrolidine-3-Carboxylic Acid Methyl Ester; 1-(Benzyloxycarbonyl)-3-methylpyrrolidine-3-carboxylic acid methyl ester; 3-Methyl-1-[(phenylmethoxy)carbonyl]-3-pyrrolidinecarboxylic acid methyl ester; 1-Carbobenzoxy-3-methylpyrrolidine-3-carboxylic acid methyl ester; N-Cbz-3-Methyl-3-pyrrolidinecarboxylic acid methyl ester; 912444-74-7
EINECS	Contact for details

Quality Control

Our Methyl 1-Cbz-3-Methylpyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.