Description

1-n-Boc-3-(S)-Methylamino-Piperidine is a high-purity, chirally pure piperidine derivative used as a critical building block in advanced organic synthesis. Its value lies in providing a protected amine functionality and a stereogenic center essential for constructing complex molecules with high enantiomeric purity. This intermediate is primarily needed by pharmaceutical R&D and production teams for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• API Development: Used in constructing the core scaffold or side chains of potential Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical reactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes.
• Peptidomimetics: Incorporated into the design of peptide-like compounds to enhance metabolic stability and bioavailability.
• Custom Synthesis: A foundational block for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-n-Boc-3-(S)-Methylamino-Piperidine
CAS No.	912368-73-1
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	(S)-1-Boc-3-(Methylamino)piperidine; (S)-3-(Methylamino)-1-(tert-butoxycarbonyl)piperidine; tert-Butyl (3S)-3-(methylamino)piperidine-1-carboxylate; (S)-1-N-Boc-3-(Methylamino)piperidine; 1-Boc-3-((S)-methylamino)piperidine; (S)-1-(tert-Butoxycarbonyl)-3-(methylamino)piperidine; 1-N-Boc-3-(S)-Methylaminopiperidine
EINECS	Contact for details

Quality Control

Our 1-n-Boc-3-(S)-Methylamino-Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.