Description

Halobetasol Spiro Analog is a high-purity synthetic steroid derivative, serving as a key intermediate in advanced pharmaceutical research and development. Its primary value lies in enabling the synthesis and study of novel corticosteroid compounds with targeted therapeutic effects. This compound is essential for R&D laboratories and manufacturers in the pharmaceutical and fine chemical sectors focused on dermatological and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel corticosteroid APIs, particularly in the halobetasol family.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new topical anti-inflammatory agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for potent glucocorticoid receptor agonists.

Basic Information

Product Name	Halobetasol Spiro Analog
CAS No.	912360-04-4
Molecular Formula	C24H31ClF2O5
Molecular Weight	472.95 g/mol
Synonyms	21-Chloro-6α,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 21-Chloro-6α,9-difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-acetonide; Halobetasol related compound; Halobetasol impurity; Halobetasol spiroketal analog; Ulocortanol spiro analog; CRM 10063
EINECS	Contact for details

Quality Control

Our Halobetasol Spiro Analog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.