Description

Deacetyl (R)-Linezolid is a key chiral intermediate in the synthesis of the oxazolidinone class of antibiotics. This high-purity compound is critical for pharmaceutical manufacturers requiring precise stereochemistry to ensure the efficacy and safety of the final active pharmaceutical ingredient (API). It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical industry for the development and scalable manufacturing of novel antibacterial agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of (R)-Linezolid and related oxazolidinone antibiotics.
• API Development: Used in research and process development for new antibacterial drug candidates targeting Gram-positive bacteria.
• Process Chemistry: Employed in route scouting and optimization studies for more efficient API manufacturing processes.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in studies exploring chiral synthesis pathways and stereoselective reactions.

Basic Information

Product Name	Deacetyl (R)-Linezolid
CAS No.	912359-80-9
Molecular Formula	C15H19FN2O3
Molecular Weight	294.32 g/mol
Synonyms	(R)-N-[[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide; (R)-Linezolid Deacetyl Intermediate; (R)-PNU-100766 Deacetyl; (R)-3-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-5-oxazolidinemethanol Acetamide Derivative; (R)-U-100766 Deacetyl; Zyvox Intermediate (R)-Deacetyl; (5R)-5-(Acetylaminomethyl)-3-(3-fluoro-4-morpholin-4-ylphenyl)-1,3-oxazolidin-2-one
EINECS	Contact for details

Quality Control

Our Deacetyl (R)-Linezolid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R)-isomer
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.