Description

(10S,11S)-8-Chloro-11-((Methylamino)Methyl)-10,11-Dihydrodibenzo[B,F]Oxepine-10-Carboxylic Acid CAS NO 912355-99-8 is a high-purity, chiral pharmaceutical intermediate characterized by its complex dibenzooxepine core structure. This compound is of significant value for its role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents, particularly within the central nervous system (CNS) and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies, lead optimization, and the discovery of new bioactive molecules.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Utilized as an analytical standard for quality control, method validation, and regulatory submissions in pharmaceutical analysis.
• Asymmetric Synthesis: Its defined stereochemistry makes it valuable for constructing other chiral molecules in enantioselective synthesis.

Basic Information

Item	Detail
Product Name	(10S,11S)-8-Chloro-11-((Methylamino)Methyl)-10,11-Dihydrodibenzo[B,F]Oxepine-10-Carboxylic Acid
CAS No.	912355-99-8
Molecular Formula	C18H18ClNO3
Molecular Weight	331.79 g/mol
Synonyms	(10S,11S)-8-Chloro-11-[(methylamino)methyl]-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid; 8-Chloro-11-((methylamino)methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid (10S,11S)-; Dibenzo[b,f]oxepine-10-carboxylic acid, 8-chloro-10,11-dihydro-11-[(methylamino)methyl]-, (10S,11S)-; (10S,11S)-8-Chloro-11-(methylaminomethyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid; CAS 912355-99-8
EINECS	Contact for details

Quality Control

Our (10S,11S)-8-Chloro-11-((Methylamino)Methyl)-10,11-Dihydrodibenzo[B,F]Oxepine-10-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.