Description

Methyl (2S,3R)-3-[(3-Fluoro-4-Nitro)Phenyl]-3-Hydroxy-2-(n-Methylamino)Propionate CAS NO 912341-89-0 is a high-purity, chiral synthetic intermediate of significant importance in modern pharmaceutical research and development. Its complex stereochemistry and functional groups make it a valuable building block for constructing advanced active pharmaceutical ingredients (APIs). This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders and other specialized therapeutics.
• Asymmetric Synthesis: Utilized as a critical precursor in stereoselective synthesis routes to introduce specific (2S,3R) configurations into complex molecular architectures.
• API Development: Serves as a building block in the pilot-scale and commercial-scale synthesis of advanced Active Pharmaceutical Ingredients (APIs) requiring high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities and optimize pharmacological properties.
• Process Chemistry: Used for developing and scaling up efficient, cost-effective synthetic pathways for complex chiral molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Methyl (2S,3R)-3-[(3-Fluoro-4-Nitro)Phenyl]-3-Hydroxy-2-(n-Methylamino)Propionate
CAS No.	912341-89-0
Molecular Formula	C11H13FN2O5
Molecular Weight	272.23 g/mol
Synonyms	Methyl (2S,3R)-3-(3-fluoro-4-nitrophenyl)-3-hydroxy-2-(methylamino)propanoate; (2S,3R)-Methyl 3-hydroxy-2-(methylamino)-3-(3-fluoro-4-nitrophenyl)propionate; (2S,3R)-3-(3-Fluoro-4-nitrophenyl)-3-hydroxy-2-(methylamino)propionic acid methyl ester; 912341-89-0; (S,R)-enantiomer of the methyl ester; Fluoronitro phenyl hydroxy methylamino propionate methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl (2S,3R)-3-[(3-Fluoro-4-Nitro)Phenyl]-3-Hydroxy-2-(n-Methylamino)Propionate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and related substances is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.