Description

(R)-6,8-Difluoro-Chroman-4-Ylamine CAS NO 912260-01-6 is a high-purity chiral building block and key pharmaceutical intermediate of significant synthetic value. Its core value lies in its enantiomerically pure structure, which is essential for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of novel, targeted molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides for enhanced efficacy and environmental profile.
• Asymmetric Catalysis Research: Serves as a valuable ligand precursor or chiral scaffold in academic and industrial research focused on asymmetric synthesis methodologies.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Fine Chemical Manufacturing: A key starting material for the multi-step synthesis of complex, fluorinated organic molecules with specific optical activity.

Basic Information

Product Name	(R)-6,8-Difluoro-Chroman-4-Ylamine
CAS No.	912260-01-6
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	(R)-6,8-Difluorochroman-4-amine; (4R)-6,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-6,8-Difluoro-3,4-dihydro-2H-chromen-4-amine; (R)-4-Amino-6,8-difluorochroman; 6,8-Difluorochroman-4-amine (R-enantiomer); (R)-4-Amino-6,8-difluoro-3,4-dihydro-2H-chromene; (R)-6,8-Difluoro-4-chromanamine
EINECS	Contact for details

Quality Control

Our (R)-6,8-Difluoro-Chroman-4-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be stored away from light. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.