Description

(2R,4R)-2-Phenyl-Tetrahydro-2H-Pyran-4-Amine is a chiral amine derivative of tetrahydropyran, serving as a high-value building block in advanced organic synthesis. Its defined stereochemistry and functional group versatility make it a critical intermediate for constructing complex molecular architectures with precise spatial orientation. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Catalysis: Used as a precursor for synthesizing chiral ligands and organocatalysts in enantioselective synthesis.
• Agrochemical Research: Employed in the creation of new chiral active ingredients for herbicides and fungicides.
• Chemical Biology & Proteomics: Serves as a scaffold or linker in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science: Potential monomer or additive for developing specialty polymers with specific optical or mechanical properties.

Basic Information

Product Name	(2R,4R)-2-Phenyl-Tetrahydro-2H-Pyran-4-Amine
CAS No.	911826-56-7
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	(2R,4R)-2-Phenyl-4-aminotetrahydropyran; (2R,4R)-2-Phenyltetrahydro-2H-pyran-4-amine; 4-Amino-2-phenyltetrahydropyran, (2R,4R)-; (2R,4R)-4-Amino-2-phenyltetrahydro-2H-pyran; 2-Phenyl-4-aminotetrahydropyran (R,R)-isomer; (R,R)-2-Phenyltetrahydropyran-4-amine; 911826-56-7; (2R-cis)-2-Phenyl-4-aminotetrahydropyran
EINECS	Contact for details

Quality Control

Our (2R,4R)-2-Phenyl-Tetrahydro-2H-Pyran-4-Amine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.