Description

(R)-5,8-Difluoro-Chroman-4-Ylamine CAS NO 911826-12-5 is a chiral, fluorinated chroman derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate for the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new therapeutic agents, particularly those targeting central nervous system and cardiovascular diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in the construction of complex molecules requiring the specific (R)-enantiomer configuration for optimal biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Fluorinated Compound Library Synthesis: A valuable scaffold for creating libraries of fluorinated compounds to explore new chemical space in drug discovery.
• Preclinical Development: Serves as a starting material for producing compounds used in pharmacological and toxicological studies.

Basic Information

Product Name	(R)-5,8-Difluoro-Chroman-4-Ylamine
CAS No.	911826-12-5
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	(R)-5,8-Difluorochroman-4-amine; (4R)-5,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-5,8-Difluoro-3,4-dihydro-2H-chromen-4-amine; (R)-5,8-Difluoro-4-aminochroman; 5,8-Difluoro-4-chromanamine (R)-; (R)-4-Amino-5,8-difluorochroman
EINECS	Contact for details

Quality Control

Our (R)-5,8-Difluoro-Chroman-4-Ylamine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity. We adhere to cGMP principles where applicable to support our clients' development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.