Description

(R)-7-Fluorochroman-4-Amine is a chiral, fluorinated chroman derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique stereochemistry and fluorine atom into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of central nervous system (CNS) targeted drugs, serotonin receptor modulators, and other bioactive molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the chroman scaffold and fluorine substitution can enhance biological activity and metabolic stability.
• Asymmetric Catalysis: Employed as a chiral ligand precursor or a substrate in asymmetric synthesis to induce stereoselectivity in chemical transformations.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex, fluorinated organic compounds for material science and specialty chemical applications.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(R)-7-Fluorochroman-4-Amine
CAS No.	911826-11-4
Molecular Formula	C9H10FNO
Molecular Weight	167.18 g/mol
Synonyms	(R)-7-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (4R)-7-Fluoro-3,4-dihydro-2H-chromen-4-amine; (R)-7-Fluoro-4-aminochroman; 7-Fluoro-4-aminochroman (R-enantiomer); (R)-4-Amino-7-fluorochroman; (R)-7-Fluorochroman-4-ylamine; (R)-4-Amino-7-fluoro-3,4-dihydro-2H-chromene
EINECS	Contact for details

Quality Control

Our (R)-7-Fluorochroman-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.