Description

(4R)-6,8-Difluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. Its defined stereochemistry and functionalized benzopyran core make it a critical precursor for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the synthesis of fluorinated bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and production of potential drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis due to its fluorinated benzopyran structure.
• Process Chemistry & Scale-up: Employed in route scouting, optimization, and pilot-scale synthesis for new chemical entities (NCEs).
• Asymmetric Synthesis: The (4R) stereocenter provides a handle for constructing complex molecules with defined chirality, crucial for enantioselective drug development.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	(4R)-6,8-Difluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride
CAS No.	911826-06-7
Molecular Formula	C9H9F2NO•HCl
Molecular Weight	221.63 (Free base) / 258.09 (HCl salt)
Synonyms	(4R)-6,8-Difluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride; (4R)-6,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine HCl; 6,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride, (4R)-; (R)-6,8-Difluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride; 4-Amino-6,8-difluoro-3,4-dihydro-2H-chromene hydrochloride, (4R)-; CAS 911826-06-7
EINECS	Contact for details

Quality Control

Our (4R)-6,8-Difluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.