Description

(R)-6-Fluoro-Chroman-4-Ylamine is a high-purity chiral amine building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate for synthesizing enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular therapeutic areas. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and advanced fine chemical manufacturers engaged in the development of novel, optically active drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel serotonin and norepinephrine reuptake inhibitors (SNRIs) and other CNS-targeting molecules.
• Asymmetric Synthesis: Used as a versatile chiral amine precursor in catalytic asymmetric transformations to construct complex molecular architectures.
• API Development: Critical building block in the research and scale-up phases for new chemical entities (NCEs), especially those containing the chroman scaffold.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a defined stereocenter for optimizing drug potency and selectivity.
• Process Chemistry: Employed in the development of efficient, scalable synthetic routes for GMP production of target molecules.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(R)-6-Fluoro-Chroman-4-Ylamine
CAS No.	911825-61-1
Molecular Formula	C9H10FNO
Molecular Weight	167.18 g/mol
Synonyms	(R)-6-Fluorochroman-4-amine; (4R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-4-Amino-6-fluorochromane; 6-Fluoro-(4R)-chroman-4-amine; (R)-6-Fluoro-3,4-dihydro-2H-chromen-4-amine; (R)-6-Fluoro-2,3-dihydro-4H-1-benzopyran-4-amine; (R)-6-Fluoro-4-chromanamine
EINECS	Contact for details

Quality Control

Our (R)-6-Fluoro-Chroman-4-Ylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric excess (ee) >99%, and is supported by a detailed Certificate of Analysis (COA). We adhere to ICH Q7 guidelines for active pharmaceutical ingredients, and our quality commitment ensures material suitable for use in advanced research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.