Description

4-Chloro-A-Methyl-D-Phenylalanine is a specialized non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This chiral compound serves as a critical building block for the synthesis of novel peptide-based therapeutics and bioactive molecules. It is particularly valuable for medicinal chemists and R&D teams in the pharmaceutical and biotechnology sectors who require high-purity, structurally defined intermediates to create targeted drug candidates with enhanced metabolic stability and receptor selectivity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, enzyme modulators, and other targeted small-molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a chlorinated, methylated phenylalanine analog into peptide chains, altering their conformation and biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of halogen and methyl substitutions on peptide backbone properties and drug-like characteristics.
• Bioconjugation & Probe Development: Acts as a precursor for creating labeled peptides or affinity probes used in biochemical assays and diagnostic research.
• Asymmetric Synthesis: Serves as a valuable starting material or auxiliary in asymmetric catalytic reactions due to its defined stereochemistry.

Basic Information

Product Name	4-Chloro-A-Methyl-D-Phenylalanine
CAS No.	911701-87-6
Molecular Formula	C10H12ClNO2
Molecular Weight	213.66 g/mol
Synonyms	(R)-2-Amino-3-(4-chlorophenyl)-2-methylpropanoic acid; D-4-Chloro-α-methylphenylalanine; (2R)-2-Amino-3-(4-chlorophenyl)-2-methylpropanoic acid; 4-Chloro-D-α-methylphenylalanine; 4-Chloro-α-methyl-D-phenylalanine; 4-Cl-α-Me-D-Phe-OH; 4-Chloro-α-methyl-(R)-phenylalanine
EINECS	Contact for details

Quality Control

Our 4-Chloro-A-Methyl-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.