Description

(S)-3-(tert-Butoxycarbonyl)-4-(5,5-Difluoro-2-Oxopiperidin-1-Yl)Butanoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a chiral center and a difluorinated piperidinone moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents targeting complex diseases. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex, biologically active molecules, especially protease inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its chiral purity and fluorine substitution.
• API Synthesis: Serves as a critical precursor in multi-step synthetic routes for the manufacture of Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Development: The structural motif is valuable for developing inhibitors for proteases involved in viral, oncological, and inflammatory pathways.
• Fluorinated Compound Library: An essential component for creating specialized screening libraries focused on fluorinated bioactive compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(S)-3-(tert-Butoxycarbonyl)-4-(5,5-Difluoro-2-Oxopiperidin-1-Yl)Butanoic Acid
CAS No.	911635-43-3
Molecular Formula	C14H21F2NO5
Molecular Weight	321.32 g/mol
Synonyms	(S)-3-((tert-Butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid; 1-(4-((S)-3-((tert-Butoxycarbonyl)amino)-4-carboxybutyl)-5,5-difluoropiperidin-2-one; Boc-Difluoro-homoPip-OH; (S)-3-(Boc-amino)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butyric acid; (S)-4-(5,5-Difluoro-2-oxopiperidin-1-yl)-3-((tert-butoxycarbonyl)amino)butanoic acid; (S)-3-(tert-Butoxycarbonylamino)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid
EINECS	Contact for details

Quality Control

Our production of (S)-3-(tert-Butoxycarbonyl)-4-(5,5-Difluoro-2-Oxopiperidin-1-Yl)Butanoic Acid adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity, and impurity profiles is provided with every shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.