Description

tert-Butyl 3,3-Difluoropiperidine-1-Carboxylate is a high-value, fluorinated piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the introduction of a difluorinated piperidine scaffold into target molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for creating novel active pharmaceutical ingredients (APIs) and other complex chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry: Used to incorporate the metabolically stable 3,3-difluoropiperidine moiety into lead compounds to modulate pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel pesticides and herbicides that leverage fluorine's unique properties.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Used as a monomer or modifier in the development of specialty polymers and advanced materials.
• Chemical Biology Probes: Acts as a building block for creating fluorinated probes and tags used in biochemical assays and imaging.

Basic Information

Product Name	tert-Butyl 3,3-Difluoropiperidine-1-Carboxylate
CAS No.	911634-75-8
Molecular Formula	C10H17F2NO2
Molecular Weight	221.25 g/mol
Synonyms	1-Boc-3,3-difluoropiperidine; 3,3-Difluoropiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3,3-difluoropiperidine-1-carboxylate; 1-N-Boc-3,3-difluoropiperidine; N-Boc-3,3-difluoropiperidine; Boc-3,3-difluoropiperidine; 911634-75-8; 3,3-Difluoro-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Difluoropiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with consistent quality, traceability, and documentation compliant with cGMP and ISO standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.