Description

1H-Indazole-1-Carboxylic Acid, 5-[[2-[3-[2-(1,1-Dimethylethoxy)-2-Oxoethoxy]Phenyl]-4-Quinazolinyl]Amino]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound is critical for research and development in targeted drug discovery, particularly in kinase inhibitor programs. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking reliable, high-quality building blocks for novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry: Serves as a critical intermediate in the scale-up and development of robust API manufacturing processes.
• Biochemical Research: Employed as a tool compound or precursor in biochemical assays to study specific enzyme targets and pathways.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and advanced intermediates.

Basic Information

Product Name	1H-Indazole-1-Carboxylic Acid, 5-[[2-[3-[2-(1,1-Dimethylethoxy)-2-Oxoethoxy]Phenyl]-4-Quinazolinyl]Amino]-, 1,1-Dimethylethyl Ester
CAS No.	911417-61-3
Molecular Formula	C34H35N5O6
Molecular Weight	609.68 g/mol
Synonyms	tert-Butyl 5-((2-(3-(2-(tert-butoxy)-2-oxoethoxy)phenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylate; 1H-Indazole-1-carboxylic acid, 5-[[2-[3-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]-4-quinazolinyl]amino]-, 1,1-dimethylethyl ester; 5-((2-(3-(2-(tert-Butoxy)-2-oxoethoxy)phenyl)quinazolin-4-yl)amino)-1H-indazole-1-carboxylic acid tert-butyl ester; BOC-protected indazole-quinazoline intermediate; 911417-61-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and meet stringent purity specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.