Description

(S)-4-(1-Aminoethyl)Benzonitrile Hcl CAS NO 911372-80-0 is a high-purity chiral building block and pharmaceutical intermediate. Its value lies in its well-defined stereochemistry, which is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and manufacturers in the pharmaceutical and fine chemical industries, particularly those focused on developing novel therapeutics where specific chirality is required for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Used as a starting material or precursor for constructing complex molecules with defined stereocenters via various coupling and functionalization reactions.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical building block in the research and process development of new enantiomerically pure APIs.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the design of novel bioactive compounds.
• Catalyst & Ligand Synthesis: Can be utilized in the preparation of chiral catalysts or ligands for asymmetric catalysis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-4-(1-Aminoethyl)Benzonitrile Hydrochloride
CAS No.	911372-80-0
Molecular Formula	C9H10N2·HCl
Molecular Weight	182.65 g/mol
Synonyms	(S)-4-(1-Aminoethyl)benzonitrile hydrochloride; (S)-α-Methyl-4-cyanobenzylamine hydrochloride; (S)-1-(4-Cyanophenyl)ethylamine hydrochloride; (S)-4-(1-Aminoethyl)benzonitrile HCl; Benzonitrile, 4-[(1S)-1-aminoethyl]-, hydrochloride; (S)-4-Cyanophenethylamine hydrochloride; (S)-p-Cyano-α-methylbenzylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4-(1-Aminoethyl)Benzonitrile HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from techniques such as HPLC, chiral HPLC, NMR, and mass spectrometry. Our quality commitment supports applications requiring high enantiomeric excess (ee) and meets the stringent standards expected in pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.