Description

o-tert-Butyl-Dimethylsilyl Curcumin is a chemically modified derivative of curcumin, designed to enhance its stability and bioavailability. This compound is a crucial synthetic intermediate in pharmaceutical research and development, particularly for creating novel therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and advanced chemical synthesis sectors seeking to leverage the beneficial properties of curcumin with improved pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting inflammation, cancer, and neurological disorders.
• Bioavailability Enhancement Studies: Used in R&D to develop prodrugs or analogs of curcumin with improved metabolic stability and absorption.
• Chemical Biology Research: Serves as a protected or modified probe to study curcumin's mechanism of action and interaction with biological targets.
• Nutraceutical Development: Investigated for use in advanced dietary supplement formulations requiring stabilized curcuminoid compounds.
• Organic Synthesis: Employed in complex multi-step syntheses where the tert-butyldimethylsilyl (TBDMS) protecting group is required for specific functional group manipulation.

Basic Information

Product Name	o-tert-Butyl-Dimethylsilyl Curcumin
CAS No.	911292-36-9
Molecular Formula	C25H32O6Si
Molecular Weight	456.61 g/mol
Synonyms	1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione O-tert-Butyldimethylsilyl Ether; Curcumin TBDMS Derivative; TBDMS-Curcumin; (1E,6E)-1,7-Bis(4-[(tert-butyldimethylsilyl)oxy]-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; o-TBDMS-Curcumin; tert-Butyldimethylsilyl Curcumin Ether; Bisdemethoxycurcumin TBDMS Ether (if applicable); Curcumin Bis(TBDMS) Ether
EINECS	Contact for details

Quality Control

Our o-tert-Butyl-Dimethylsilyl Curcumin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.