Description

(R)-4-Oxopyrrolidine-2-Carboxylic Acid CAS NO 911284-93-0 is a high-purity, non-proteinogenic amino acid derivative belonging to the pyrrolidine class, serving as a critical chiral building block in advanced organic synthesis. Its value lies in its role as a key precursor for synthesizing complex molecules with defined stereochemistry, essential for achieving specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals where the (R)-enantiomer's configuration is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Design: Used to incorporate constrained proline-like structures into peptide backbones to enhance metabolic stability and bioavailability in drug candidates.
• Asymmetric Synthesis: Serves as a starting material or chiral auxiliary in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Bioconjugation & Probe Development: Utilized in the synthesis of chemical probes and bioconjugates for biochemical and pharmacological research due to its functional handle for further modification.
• Agrochemical Research: Employed as a building block in the synthesis of novel, chiral agrochemicals such as herbicides and fungicides.
• Academic & Process Chemistry: A valuable reagent for methodological development in academic laboratories and for scaling up synthetic routes in process chemistry.

Basic Information

Product Name	(R)-4-Oxopyrrolidine-2-Carboxylic Acid
CAS No.	911284-93-0
Molecular Formula	C5H7NO3
Molecular Weight	129.11 g/mol
Synonyms	(R)-Pyroglutamic Acid; (R)-(-)-Pyroglutamic Acid; (R)-5-Oxoproline; D-(-)-Pyroglutamic Acid; (R)-2-Pyrrolidone-5-carboxylic Acid; (R)-PCA; (2R)-4-Oxopyrrolidine-2-carboxylic Acid; (R)-Pyroglutamate
EINECS	Contact for details

Quality Control

Our (R)-4-Oxopyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.