Description

tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Chromene-2,4'-Piperidine]-1'-Carboxylate CAS NO 911228-63-2 is a high-purity, advanced pharmaceutical intermediate featuring a spirocyclic chromene core and a protected piperidine boronic ester. This compound is a critical building block in modern medicinal chemistry, enabling the efficient synthesis of complex molecules through versatile cross-coupling reactions. It is primarily utilized by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: The boronic ester functional group makes it an ideal reagent for palladium-catalyzed coupling reactions to form carbon-carbon bonds, a cornerstone of drug discovery.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities and improve drug candidate profiles.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in early-stage drug discovery.
• Process Development: Serves as a starting material for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and catalysis.

Basic Information

Product Name	tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Chromene-2,4'-Piperidine]-1'-Carboxylate
CAS No.	911228-63-2
Molecular Formula	C24H34BNO5
Molecular Weight	427.34 g/mol
Synonyms	1'-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]; tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-spiro[chromene-2,4'-piperidine]-1'-carboxylate; 1,1-Dimethylethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-spiro[chromene-2,4'-piperidine]-1'-carboxylate; 911228-63-2; BOC-protected spirochromene boronic ester; Spiro[chromene-2,4'-piperidine]-1'-carboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Chromene-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is easily oxidized and light-sensitive. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.