Description

Rosuvastatin Substituted Hydroxy Pentenoic Acid is a key pharmaceutical intermediate in the synthesis of Rosuvastatin, a widely prescribed statin medication. This high-purity compound is critical for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the production of cardiovascular drugs.

Application

• Primary Intermediate for the synthesis of Rosuvastatin Calcium, the active ingredient in cholesterol-lowering medications.
• Research & Development of novel statin analogs and related cardiovascular therapeutics in pharmaceutical laboratories.
• Process Chemistry for scale-up and optimization of Rosuvastatin API manufacturing processes.
• Reference Standard for analytical method development and quality control in API production.
• Custom Synthesis for contract manufacturing organizations (CMOs) serving the global pharmaceutical market.

Basic Information

Product Name	Rosuvastatin Substituted Hydroxy Pentenoic Acid
CAS No.	910867-11-7
Molecular Formula	C₂₂H₂₈FN₃O₆S
Molecular Weight	481.54 g/mol
Synonyms	(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid; Rosuvastatin Intermediate; Rosuvastatin Dihydroxy Acid; (E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid; ZD4522 Intermediate
EINECS	Contact for details

Quality Control

Our Rosuvastatin Substituted Hydroxy Pentenoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure it meets stringent purity requirements suitable for pharmaceutical synthesis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.