Description

(E)-4-(4-{[(4,6-Dimethyl-2-Pyrimidinyl)Amino]Sulfonyl}Anilino)-4-Oxo-2-Butenoic Acid is a high-purity, non-nucleoside pharmaceutical intermediate of significant interest in modern drug discovery. This compound is valued for its role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting specific enzymatic pathways. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Biochemical Research: Used as a reference standard or a probe molecule in enzymatic assays and structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: Employed in medicinal chemistry for constructing molecules with specific sulfonamide and butenoic acid functionalities.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for investigating new chemical entities and their biological activities.

Basic Information

Product Name	(E)-4-(4-{[(4,6-Dimethyl-2-Pyrimidinyl)Amino]Sulfonyl}Anilino)-4-Oxo-2-Butenoic Acid
CAS No.	910621-63-5
Molecular Formula	C16H16N4O5S
Molecular Weight	376.39 g/mol
Synonyms	(E)-4-(4-((4,6-Dimethylpyrimidin-2-yl)sulfamoyl)phenylamino)-4-oxobut-2-enoic acid; 4-[(E)-2-Carboxyethenoyl]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; (E)-4-Oxo-4-[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]anilino]-2-butenoic acid; 910621-63-5; Butenoic acid, 4-[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]anilino]-4-oxo-, (E)-; Sulfonamide-based kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our (E)-4-(4-{[(4,6-Dimethyl-2-Pyrimidinyl)Amino]Sulfonyl}Anilino)-4-Oxo-2-Butenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.