Description

(S)-1-(4-(((tert-Butyldiphenylsilyl)Oxy)Methyl)Phenyl)But-3-En-1-Ol is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the production of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Asymmetric Synthesis: Used in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity, essential for modern medicinal chemistry.
• Process Chemistry & Scale-Up: Serves as a validated intermediate in the development and optimization of scalable manufacturing routes for drug candidates from laboratory to pilot plant scale.
• Academic & Contract Research: Employed in academic research and by contract research organizations (CROs) for method development and the exploration of new synthetic pathways.
• Fine Chemical Production: Utilized in the synthesis of specialty fine chemicals and advanced materials where specific chirality and functional group compatibility are required.

Basic Information

Product Name	(S)-1-(4-(((tert-Butyldiphenylsilyl)Oxy)Methyl)Phenyl)But-3-En-1-Ol
CAS No.	910610-20-7
Molecular Formula	C28H32O2Si
Molecular Weight	428.64 g/mol
Synonyms	(S)-1-[4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]phenyl]-3-buten-1-ol; (S)-1-(4-((tert-Butyldiphenylsilyloxy)methyl)phenyl)but-3-en-1-ol; (S)-4-((tert-Butyldiphenylsilyloxy)methyl)benzenepropanol, α-vinyl-; (S)-TBDPS-protected Benzylic Alcohol Derivative; (S)-1-(4-(((Tert-Butyldiphenylsilyl)Oxy)Methyl)Phenyl)-3-Buten-1-Ol; (S)-TBDPS-O-CH2-Ph-CH(OH)-CH2-CH=CH2
EINECS	Contact for details

Quality Control

Our production of (S)-1-(4-(((tert-Butyldiphenylsilyl)Oxy)Methyl)Phenyl)But-3-En-1-Ol adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for pharmaceutical R&D. All materials are characterized by advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (ee), and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.