Description

(2S,3R)-n-(tert-Butyloxycarbonyl)-3-Methyl-5-Oxo-Pyrrolidinecarboxylic Acid is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a protected amino acid intermediate, enabling the precise construction of complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially protease inhibitors and other targeted therapies.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce specific, stereochemically defined amino acid residues.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• API Development: Integral to the research and process development of new Active Pharmaceutical Ingredients (APIs) requiring specific (2S,3R) stereochemistry.
• Bioconjugation & Probe Synthesis: Useful for creating labeled peptides or molecular probes for diagnostic and biochemical research applications.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(2S,3R)-n-(tert-Butyloxycarbonyl)-3-Methyl-5-Oxo-Pyrrolidinecarboxylic Acid
CAS No.	910548-25-3
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	Boc-3-methyl-5-oxo-D-proline; (2S,3R)-1-[(tert-Butoxy)carbonyl]-3-methyl-5-oxopyrrolidine-2-carboxylic acid; Boc-D-3-methyl-5-oxoproline; tert-Butyl (2S,3R)-3-methyl-5-oxo-2-pyrrolidinecarboxylate-2-carboxylic acid; (2S,3R)-1-Boc-3-methyl-5-oxopyrrolidine-2-carboxylic acid; N-Boc-3-methyl-5-oxo-D-proline
EINECS	Contact for details

Quality Control

Our production of (2S,3R)-n-(tert-Butyloxycarbonyl)-3-Methyl-5-Oxo-Pyrrolidinecarboxylic Acid adheres to stringent quality management protocols. Each batch is thoroughly characterized and tested to ensure identity, purity, and stereochemical integrity, meeting the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Comprehensive analytical data, including HPLC for purity and chiral analysis, is documented in a batch-specific Certificate of Analysis (COA), available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.