Description

(2S,3R)-n-(tert-Butyloxycarbonyl)-3-Methyl-Pyroglutaminol CAS NO 910548-24-2 is a high-purity, chiral pyroglutamic acid derivative, serving as a critical protected intermediate in advanced organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This building block is essential for research and production chemists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for peptide mimetics and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, neuroactive peptides, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to construct constrained peptide analogs and scaffolds in medicinal chemistry to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereocontrolled reactions to introduce the (2S,3R) configuration into target molecules.
• Fine Chemical Production: Serves as a specialized building block for custom synthesis and the manufacture of high-value agrochemicals or specialty chemicals.
• Bioconjugation & Labeling: The protected amine and hydroxyl groups provide handles for further functionalization in bioconjugation chemistry.
• Academic & Industrial R&D: Utilized in research laboratories for developing new synthetic methodologies and exploring novel chemical entities.

Basic Information

Product Name	(2S,3R)-n-(tert-Butyloxycarbonyl)-3-Methyl-Pyroglutaminol
CAS No.	910548-24-2
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	(2S,3R)-1-[(tert-Butoxycarbonyl)]-3-methyl-5-oxopyrrolidine-2-carboxamide; (2S,3R)-N-Boc-3-methyl-5-oxoproline amide; tert-Butyl (2S,3R)-2-carbamoyl-3-methyl-5-oxopyrrolidine-1-carboxylate; (2S,3R)-3-Methyl-1-N-Boc-5-oxopyrrolidine-2-carboxamide; Boc-3-Me-Pyr-OH-NH2; (2S,3R)-Boc-3-methylpyroglutaminol; 910548-24-2; 1-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-5-oxo-D-prolinamide (2S,3R)-form
EINECS	Contact for details

Quality Control

Our (2S,3R)-n-(tert-Butyloxycarbonyl)-3-Methyl-Pyroglutaminol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.