Description

1-(2-Bromoethoxy)-2-(Trifluoromethyl)Benzene is a versatile and high-value aromatic building block containing both a bromoethoxy linker and a trifluoromethyl group. This compound matters for its unique reactivity, where the bromoethoxy side chain serves as an excellent alkylating agent, while the electron-withdrawing trifluoromethyl group imparts desirable properties like enhanced metabolic stability and lipophilicity to final molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in constructing molecules with ether linkages and fluorine-containing motifs for improved drug-like properties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorine-containing aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Specialty Chemical Modifier: Employed to introduce functional aromatic ether units into polymer chains or specialty chemicals to alter physical and chemical characteristics.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-(2-Bromoethoxy)-2-(Trifluoromethyl)Benzene
CAS No.	910468-48-3
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	2-(2-Bromoethoxy)benzotrifluoride; 1-Bromo-2-[2-(trifluoromethyl)phenoxy]ethane; α-Bromo-ω-(2-trifluoromethylphenoxy)ethane; 2-(Trifluoromethyl)phenyl 2-bromoethyl ether; o-Trifluoromethylphenyl 2-bromoethyl ether; 2-Bromoethyl 2-trifluoromethylphenyl ether; Benzene, 1-(2-bromoethoxy)-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-(2-Bromoethoxy)-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.