Description

2-Aminomethyl-3-(2-Trifluoromethoxy-Phenyl)-Propionic Acid is a specialized, high-value pharmaceutical intermediate featuring a unique trifluoromethoxy-substituted phenylalanine backbone. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation therapeutics with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates.
• Protease Inhibitor Synthesis: Used in constructing molecules that inhibit specific enzymes, such as those involved in viral replication or inflammatory pathways.
• Neurological Drug Development: Serves as a precursor for compounds targeting CNS receptors and transporters.
• Peptidomimetics: Incorporated into peptide-like structures to improve drug-like properties, including membrane permeability and resistance to enzymatic degradation.
• Chemical Biology Research: Employed as a tool compound or labeled probe for studying biological mechanisms and protein interactions.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents with fluorinated motifs.

Basic Information

Product Name	2-Aminomethyl-3-(2-Trifluoromethoxy-Phenyl)-Propionic Acid
CAS No.	910443-92-4
Molecular Formula	C12H14F3NO3
Molecular Weight	277.24 g/mol
Synonyms	2-(Aminomethyl)-3-[2-(trifluoromethoxy)phenyl]propanoic acid; 3-(2-Trifluoromethoxyphenyl)-2-aminomethyl-propionic acid; 2-Aminomethyl-3-(2-trifluoromethoxy-phenyl)-propionic acid; 2-(Aminomethyl)-3-(2-(trifluoromethoxy)phenyl)propionic acid; (2R/S)-2-(Aminomethyl)-3-[2-(trifluoromethoxy)phenyl]propanoic acid (racemic mixture); β-Amino acid derivative with trifluoromethoxy phenyl group; TFMPA derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Aminomethyl-3-(2-Trifluoromethoxy-Phenyl)-Propionic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.