Description

o-Demethyl Vandetanib is a key pharmaceutical intermediate and metabolite of the active drug Vandetanib. This compound matters significantly for its critical role in the research, development, and quality control of targeted cancer therapies. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the production of tyrosine kinase inhibitors for oncology applications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and process development of Vandetanib and related analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the drug's metabolism, efficacy, and safety profile.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the purity of Vandetanib active pharmaceutical ingredient (API) batches.
• Biochemical Research: Utilized in in-vitro studies to investigate the structure-activity relationships (SAR) of kinase inhibitors.

Basic Information

Product Name	o-Demethyl Vandetanib
CAS No.	910298-60-1
Molecular Formula	C22H24BrF2N4O2
Molecular Weight	503.35 g/mol
Synonyms	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; Vandetanib Impurity; Vandetanib Metabolite; ZD6474 Metabolite; UNII-9T9B5S3A4R; AZD-6474 Metabolite; 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]quinazoline
EINECS	Contact for details

Quality Control

Our o-Demethyl Vandetanib is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.