Description

Des-6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-6-Chloro Dasatinib is a key synthetic intermediate and derivative of the tyrosine kinase inhibitor Dasatinib. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel Dasatinib analogs and for conducting structure-activity relationship (SAR) studies. It is primarily required by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of Dasatinib and its structural derivatives.
• Drug Discovery Research: Used in medicinal chemistry programs to explore new kinase inhibitor candidates and optimize pharmacological profiles.
• Process Development: Serves as a reference standard and starting material for scaling up and optimizing synthetic routes in API manufacturing.
• Biochemical Research: Employed in vitro studies to investigate the specific effects of structural modifications on kinase binding and inhibition.
• Analytical Standard: Used as a high-purity reference compound for method development and quality control (HPLC, LC-MS) in analytical laboratories.

Basic Information

Item	Detail
Product Name	Des-6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-6-Chloro Dasatinib
CAS No.	910297-71-1
Molecular Formula	C22H26ClN7O2S
Molecular Weight	487.99 g/mol
Synonyms	6-Chloro-N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; Dasatinib Derivative; Dasatinib Impurity; Dasatinib Intermediate; BMS-354825 Derivative; Des-6-Piperazinyl-6-Chloro Dasatinib; N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
EINECS	Contact for details

Quality Control

Our Des-6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-6-Chloro Dasatinib is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR, MS), to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.