Description

Des-6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-6-Chloro-o-Pivalate Dasatinib is a key pharmaceutical intermediate and a derivative of the active pharmaceutical ingredient Dasatinib. This compound is critical for research and development in the synthesis of targeted cancer therapies, particularly tyrosine kinase inhibitors. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in oncology drug development and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of Dasatinib API and its novel analogs.
• Oncology Research: Used in preclinical and discovery-phase research to study structure-activity relationships (SAR) and develop next-generation kinase inhibitors.
• Process Development & Scale-up: Employed in optimizing synthetic routes for the commercial manufacturing of Dasatinib, aiming for higher yield and purity.
• Reference Standard: Functions as a high-purity chemical reference standard for analytical method development and quality control in API production.
• Chemical Biology Studies: Utilized as a probe or tool compound in biochemical assays to investigate specific kinase signaling pathways.

Basic Information

Product Name	Des-6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-6-Chloro-o-Pivalate Dasatinib
CAS No.	910297-70-0
Molecular Formula	C26H32ClN5O3S
Molecular Weight	530.08 g/mol
Synonyms	Dasatinib Des-6 Derivative; Dasatinib N-Desmethyl Piperazine Ester; 6-Chloro-2-((2-chloro-6-methylpyrimidin-4-yl)amino)-N-(2-hydroxyethyl)-N-(4-(2-hydroxyethyl)piperazin-1-yl)thiazole-5-carboxamide pivalate ester; BMS-354825 Derivative; Des-6-(2-Hydroxyethylpiperazinyl) Dasatinib Chloro Pivalate; Sprycel Intermediate; UNII-7K00L6T4FJ (component)
EINECS	Contact for details

Quality Control

Our Des-6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-6-Chloro-o-Pivalate Dasatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and current industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.