Description

Hydroxymethyl Dasatinib is a key pharmaceutical intermediate and a chemically modified derivative of the tyrosine kinase inhibitor Dasatinib. This compound is primarily utilized in advanced research and development for the synthesis of novel therapeutic agents targeting specific cancer pathways. It is essential for pharmaceutical manufacturers and research institutions focused on oncology drug discovery and process chemistry. The material is characterized by its high purity and is critical for ensuring the efficacy and consistency of downstream active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of Dasatinib analogs and next-generation kinase inhibitors.
• Oncology Research: Used in preclinical and discovery-phase studies to investigate structure-activity relationships (SAR) and develop targeted cancer therapies.
• Process Chemistry Development: Employed in optimizing scalable synthetic routes for the production of tyrosine kinase inhibitor APIs under Good Manufacturing Practice (GMP) guidelines.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Bioconjugation Studies: Utilized in research exploring antibody-drug conjugates (ADCs) or other targeted drug delivery systems due to its modifiable hydroxymethyl group.

Basic Information

Product Name	Hydroxymethyl Dasatinib
CAS No.	910297-58-4
Molecular Formula	C23H28ClN7O3S
Molecular Weight	518.03 g/mol
Synonyms	N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; Dasatinib Hydroxymethyl Derivative; BMS-354825 Hydroxymethyl Analog; Hydroxymethyl Dasatinib Monohydrate (common form); 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-; Hydroxyethylpiperazinyl Dasatinib Precursor
EINECS	Contact for details

Quality Control

Our Hydroxymethyl Dasatinib is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical development. Quality is verified through comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.