Description

Dasatinib Carboxylic Acid is a key pharmaceutical intermediate and a crucial building block in synthetic organic chemistry. This compound matters for its role in the development and production of targeted cancer therapies, specifically as a precursor to the active pharmaceutical ingredient Dasatinib. It is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in oncology drug synthesis and advanced chemical process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of Dasatinib, a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).
• Research & Development: Used in medicinal chemistry for the design, optimization, and synthesis of novel kinase inhibitor analogs and new chemical entities (NCEs) for oncology research.
• Process Chemistry: Serves as a high-value starting material or intermediate in scale-up and process optimization for API (Active Pharmaceutical Ingredient) manufacturing under GMP conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development, validation, and impurity profiling of Dasatinib API and related substances.
• Custom Synthesis: A building block for contract research organizations (CROs) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	Dasatinib Carboxylic Acid
CAS No.	910297-53-9
Molecular Formula	C22H26ClN7O3S
Molecular Weight	504.01 g/mol
Synonyms	Dasatinib Impurity 11; Dasatinib Carboxylic Acid Impurity; Dasatinib Related Compound A; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; BMS-354825 Carboxylic Acid; 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
EINECS	Contact for details

Quality Control

Our Dasatinib Carboxylic Acid is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for pharmaceutical R&D and advanced synthesis. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with ICH guidelines for impurities and can supply material tailored to specific pharmacopeial or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥98.5%
Single Unknown Impurity	≤0.5%
Total Impurities	≤1.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.