Description

n-Deshydroxyethyl Dasatinib is a key pharmaceutical intermediate and reference standard used in the development and quality control of active pharmaceutical ingredients (APIs). This compound is of significant value for research and manufacturing processes requiring high-purity building blocks for kinase inhibitor synthesis. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and analytical service providers engaged in oncology drug development and generic pharmaceutical production.

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for Dasatinib and related kinase inhibitor APIs.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical testing laboratories.
• Process Research & Development (R&D): Employed in route scouting, optimization, and impurity profiling studies for generic drug applications.
• Metabolite Studies: Serves as a relevant compound for investigating the metabolic pathways and degradation products of Dasatinib.
• Academic & Contract Research: Used in biochemical and pharmacological research focused on tyrosine kinase inhibition mechanisms.

Basic Information

Item	Details
Product Name	n-Deshydroxyethyl Dasatinib
CAS No.	910297-51-7
Molecular Formula	C21H20ClN7O2S
Molecular Weight	469.95 g/mol
Synonyms	N-Deshydroxyethyl Dasatinib; Dasatinib Impurity; Dasatinib Related Compound; BMS-354825 Impurity; 2-Amino-N-(2-chloro-6-methylphenyl)-4-(1-methyl-1H-imidazol-2-yl)pyrimidine-5-carboxamide; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide Derivative; Dasatinib N-Deshydroxyethyl Analog
EINECS	Contact for details

Quality Control

Our n-Deshydroxyethyl Dasatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.