Description

Potassium Cyclopropylmethoxy)Methyltrifluoroborate is a high-purity organotrifluoroborate salt, a versatile and stable reagent for advanced organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to introduce the cyclopropylmethoxymethyl moiety, a valuable structural motif in medicinal chemistry. This compound is essential for researchers and process chemists in pharmaceutical R&D and fine chemical manufacturing who require reliable, high-quality building blocks for creating complex molecules and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex drug candidates, particularly those requiring the cyclopropylmethoxymethyl group.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant organoboron reagent for palladium-catalyzed C-C bond formation.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore structure-activity relationships (SAR).
• Agrochemical Research: Employed in the synthesis of novel active ingredients for crop protection.
• Material Science Precursor: Potential use in creating specialized organic materials and ligands for catalysis.
• Process Chemistry & Scale-up: Suitable for transitioning from milligram to kilogram-scale production in API manufacturing.

Basic Information

Product Name	Potassium Cyclopropylmethoxy)Methyltrifluoroborate
CAS No.	910251-14-8
Molecular Formula	C6H11BF3KO2
Molecular Weight	210.06 g/mol
Synonyms	Potassium (Cyclopropylmethoxy)methyltrifluoroborate; Potassium [(Cyclopropylmethoxy)methyl]trifluoroborate; (Cyclopropylmethoxy)methyltrifluoroborate Potassium Salt; Trifluoro[(cyclopropylmethoxy)methyl]borate Potassium; Potassium Trifluoro[(cyclopropylmethoxy)methyl]borate(1-); Potassium (Cyclopropylmethoxymethyl)trifluoroborate
EINECS	Contact for details

Quality Control

Our Potassium Cyclopropylmethoxy)Methyltrifluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 11B, 13C, 19F) and HPLC analysis, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
11B NMR Purity	≥ 95%
19F NMR Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.