Description

R-Duloxetine Hydrochloride CAS NO 910138-96-4 is a high-purity, single-enantiomer pharmaceutical intermediate of significant commercial and therapeutic importance. This compound serves as the key chiral building block for the synthesis of Duloxetine, a widely prescribed serotonin-norepinephrine reuptake inhibitor (SNRI). It is essential for manufacturers in the global pharmaceutical industry requiring a reliable, high-quality source for producing active pharmaceutical ingredients (APIs) with stringent enantiomeric purity standards.

Application

• Pharmaceutical API Synthesis: Primary use as the critical chiral intermediate in the commercial production of Duloxetine hydrochloride API.
• Neurological Disorder Treatments: Enables the manufacture of medications for major depressive disorder (MDD) and generalized anxiety disorder (GAD).
• Chronic Pain Management: Used in the production of therapies for diabetic peripheral neuropathic pain and fibromyalgia.
• Process Development & Research: Serves as a reference standard and starting material for novel synthetic route development in R&D laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial batch production.
• Regulatory Filings: Provides the necessary quality-grade material for Drug Master File (DMF) submissions and regulatory compliance documentation.

Basic Information

Product Name	R-Duloxetine Hydrochloride
CAS No.	910138-96-4
Molecular Formula	C18H20NOS•HCl
Molecular Weight	333.87 g/mol
Synonyms	(R)-Duloxetine Hydrochloride; (R)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine Hydrochloride; (R)-(+)-Duloxetine HCl; (R)-LY248686 Hydrochloride; R-enantiomer of Duloxetine HCl; UNII-9044SC542W; (R)-3-(N-Methylamino)-1-(2-thienyl)-1-(naphthalen-1-yloxy)propane Hydrochloride
EINECS	Contact for details

Quality Control

Our R-Duloxetine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (typically >99.5%), to ensure it meets the stringent requirements for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 99.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.5% (R-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 0.5% Any single impurity ≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.