Description

n-[(1S)-1-(Hydroxydiphenylmethyl)-3-Methylbutyl]-L-Prolinamide is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block or intermediate for the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel therapeutics targeting neurological and metabolic disorders. The precise stereochemistry and functional groups of this molecule make it a valuable scaffold for creating potent and selective active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Peptidomimetic Research: Used in the design and construction of peptide analogs and mimetics to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Serves as a precursor for developing novel chiral ligands or organocatalysts used in stereoselective synthesis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize lead compounds for potency and selectivity.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in API manufacturing.
• Bioconjugation: Potential use in the synthesis of antibody-drug conjugates (ADCs) or other targeted drug delivery systems due to its functional handles.

Basic Information

Product Name	n-[(1S)-1-(Hydroxydiphenylmethyl)-3-Methylbutyl]-L-Prolinamide
CAS No.	910110-45-1
Molecular Formula	C23H30N2O2
Molecular Weight	366.50 g/mol
Synonyms	(S)-N-[1-(Hydroxydiphenylmethyl)-3-methylbutyl]-L-prolinamide; L-Prolinamide, N-[(1S)-1-(hydroxydiphenylmethyl)-3-methylbutyl]-; (1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl-L-prolinamide; UNII-7V9Q8T95J8; 7V9Q8T95J8; CHEMBL3183452; ZINC000003869007; SCHEMBL15450497
EINECS	Contact for details

Quality Control

Our n-[(1S)-1-(Hydroxydiphenylmethyl)-3-Methylbutyl]-L-Prolinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and the absence of critical impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.