Description

Fmoc-D-Arg(Z)2-Oh is a protected derivative of D-Arginine, a non-natural enantiomer of the essential amino acid, widely utilized in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, enantiomerically pure building blocks to construct complex peptides with specific chiral configurations. It is primarily needed by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: For the research and production of peptide-based drugs, including hormone analogs and antimicrobial peptides.
• Bioconjugation: Used to introduce D-arginine residues into proteins or other biomolecules for stability or functional studies.
• Biochemical Research: As a standard or reagent in studies of enzyme specificity, peptide structure-activity relationships (SAR), and chiral recognition.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening of bioactive compounds.
• Proteomics: For the synthesis of isotopically labeled or modified peptide standards used in mass spectrometry.

Basic Information

Product Name	Fmoc-D-Arg(Z)2-Oh
CAS No.	910056-53-0
Molecular Formula	C₃₀H₃₂N₄O₇
Molecular Weight	560.60 g/mol
Synonyms	Fmoc-D-Arg(Z)2-OH; N-α-Fmoc-N-ω,ω'-bis(benzyloxycarbonyl)-D-arginine; Fmoc-D-Arg(Boc)2-OH (common alternate protection); (2R)-5-[[(Benzyloxy)carbonyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-N-[(benzyloxy)carbonyl]pentanamide; Fmoc-D-Arg(Z)₂-OH; N-α-(9-Fluorenylmethyloxycarbonyl)-N-ω,ω'-bis(benzyloxycarbonyl)-D-arginine; Fmoc-D-Arg(Boc)₂-OH (common error/alternative); D-Arg(Fmoc,Z,Z)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Arg(Z)2-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality control protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.