Description

Fmoc-N-Me-Gln-OH is a protected, N-methylated derivative of the amino acid glutamine, designed for use in advanced solid-phase peptide synthesis (SPPS). This specialized building block is critical for introducing conformational constraints and enhancing the metabolic stability of synthetic peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the controlled assembly of complex peptide sequences.
• Peptidomimetic Drug Discovery: Incorporation of N-methylation to improve peptide bioavailability, membrane permeability, and proteolytic resistance.
• Conformational Studies: Used to probe structure-activity relationships (SAR) by restricting peptide backbone flexibility.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse libraries of modified peptides for high-throughput screening.
• Bioconjugation and Probe Development: Facilitates the synthesis of labeled peptide probes for imaging, targeting, and diagnostic applications.
• Academic and Industrial Research: Essential reagent for synthetic chemistry and biochemistry laboratories focusing on peptide science.

Basic Information

Product Name	Fmoc-N-Me-Gln-OH
CAS No.	910056-51-8
Molecular Formula	C₂₁H₂₂N₂O₅
Molecular Weight	382.41 g/mol
Synonyms	Fmoc-N-methyl-L-glutamine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-glutamine; (2S)-5-Amino-2-[[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino]-5-oxopentanoic acid; Fmoc-N-Me-L-glutamine; Fmoc-N(Me)-Gln-OH; Nα-Fmoc-N-methyl-L-glutamine; N-Fmoc-N-methylglutamine
EINECS	Contact for details

Quality Control

Our Fmoc-N-Me-Gln-OH is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.