Description

3,4,5-Trifluoro-Benzamidine Hydrochloride is a high-purity, fluorinated benzamidine derivative essential for advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor programs. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates targeting various diseases.
• Protease Inhibitor Development: Used to construct the amidine moiety in serine protease inhibitor scaffolds.
• Kinase Inhibitor Research: Serves as a building block for creating potent and selective kinase inhibitors.
• Agrochemical Synthesis: Employed in the research and development of new fluorinated pesticides and herbicides.
• Chemical Biology Probes: Useful for creating activity-based probes to study enzyme function and mechanism.
• Material Science Research: Potential monomer or precursor for advanced fluorinated polymers with unique properties.

Basic Information

Product Name	3,4,5-Trifluoro-Benzamidine Hydrochloride
CAS No.	910053-71-3
Molecular Formula	C7H6ClF3N2
Molecular Weight	218.58 g/mol
Synonyms	3,4,5-Trifluorobenzamidine hydrochloride; 3,4,5-Trifluorobenzene carboximidamide hydrochloride; Benzenecarboximidamide, 3,4,5-trifluoro-, hydrochloride (1:1); 3,4,5-Trifluorobenzamidine HCl; 3,4,5-Trifluoro-benzamidine HCl salt; 3,4,5-Trifluorobenzimidamide hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3,4,5-Trifluoro-Benzamidine Hydrochloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.