Description

1-((2R,3R,4R,5R)-3-Fluoro-4-((Tetrahydro-2H-Pyran-2-Yl)Oxy)-5-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a sophisticated fluorinated nucleoside derivative, serving as a critical pharmaceutical intermediate in advanced synthesis. Its primary value lies in its role as a key building block for the development of novel antiviral and anticancer therapeutics, particularly nucleoside analogs. This high-purity compound is essential for research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analog drugs.
• Antiviral Drug Development: Used in research and production of therapeutics targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a building block for developing chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Used in studies exploring enzyme mechanisms, nucleotide metabolism, and structure-activity relationships (SAR).
• Labeled Compound Synthesis: A starting material for preparing isotopically labeled (e.g., C-13, N-15, F-18) compounds for metabolic and imaging studies.

Basic Information

Product Name	1-((2R,3R,4R,5R)-3-Fluoro-4-((Tetrahydro-2H-Pyran-2-Yl)Oxy)-5-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	910027-33-7
Molecular Formula	C20H29FN2O8
Molecular Weight	444.46 g/mol
Synonyms	5-Methyl-2'-deoxy-2'-fluoro-5'-O-(tetrahydro-2H-pyran-2-yl)uridine 3'-O-(tetrahydro-2H-pyran-2-yl) ether; 2'-F-5-Me-Uridine bis-THP derivative; 1-[(2R,3R,4R,5R)-3-Fluoro-4-(tetrahydro-2H-pyran-2-yloxy)-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Fluoro-5-methyluridine bis-THP ether; Fluorinated nucleoside THP-protected intermediate; 5-Methyl-2'-deoxy-2'-fluorouridine 3',5'-bis-O-(tetrahydropyran-2-yl); 2'-F-5-Me-UR bis-THP
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide full traceability and Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Specifications are designed to meet the stringent requirements of pharmaceutical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong alkalis and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.