Description

(S)-2-Amino-3-(3-Fluoro-4-Hydroxyphenyl)Propanoic Acid Hydrochloride is a high-purity, non-natural amino acid derivative, specifically the hydrochloride salt of a fluorinated phenylalanine analogue. This compound is a critical chiral building block for the synthesis of advanced pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutics, particularly in areas targeting metabolic and neurological disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially peptidomimetics and enzyme inhibitors.
• API Synthesis: Used in the production route of Active Pharmaceutical Ingredients (APIs) that incorporate fluorinated aromatic amino acid motifs to enhance metabolic stability and binding affinity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Peptide Chemistry: Employed in solid-phase and solution-phase peptide synthesis to introduce fluorinated tyrosine/phenylalanine analogues into peptide sequences, modifying their physical and biological properties.
• Proteomics & Labeling: Potential use in creating specialized probes or tags for mass spectrometry and other proteomic research techniques.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: Can be used to derive chiral ligands or organocatalysts for asymmetric transformations.

Basic Information

Product Name	(S)-2-Amino-3-(3-Fluoro-4-Hydroxyphenyl)Propanoic Acid Hydrochloride
CAS No.	909724-63-6
Molecular Formula	C9H11FNO3 • HCl
Molecular Weight	251.65 g/mol (Free base: 215.19)
Synonyms	(S)-3-(3-Fluoro-4-hydroxyphenyl)alanine hydrochloride; Fmoc-3-Fluoro-L-tyrosine hydrochloride; 3-Fluoro-L-tyrosine HCl; (S)-2-Amino-3-(3-fluoro-4-hydroxyphenyl)propionic acid hydrochloride; L-3-Fluorotyrosine hydrochloride; (2S)-2-Azaniumyl-3-(3-fluoro-4-hydroxyphenyl)propanoate chloride; 3-F-Tyr-OH • HCl
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-(3-Fluoro-4-Hydroxyphenyl)Propanoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and cGMP starting material applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% e.e.
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.