Description

1-[1-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Carbonyl)Azetidin-3-Yl)Piperidin-4-Yl]-1,3-Dihydro-2H-Benzimidazol-2-One is a high-purity, advanced pharmaceutical intermediate designed for research and development in modern drug discovery. This compound is critical for medicinal chemists exploring novel therapeutic agents, particularly in areas targeting specific enzyme pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Protease Inhibitor Development: Serves as a core scaffold in the design and synthesis of potential protease inhibitors due to its benzimidazolone and piperidine motifs.
• Kinase-Targeted Drug Discovery: Employed in the development of small molecule inhibitors targeting specific kinase enzymes involved in various disease pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.
• Biochemical Tool Compound: Can be used to create probes for studying biological mechanisms and target validation in vitro.

Basic Information

Product Name	1-[1-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Carbonyl)Azetidin-3-Yl)Piperidin-4-Yl]-1,3-Dihydro-2H-Benzimidazol-2-One
CAS No.	909682-47-9
Molecular Formula	C23H23F3N4O2
Molecular Weight	444.45 g/mol
Synonyms	1-(1-(1-(6-(Trifluoromethyl)pyridine-3-carbonyl)azetidin-3-yl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one; 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[1-[[6-(trifluoromethyl)-3-pyridinyl]carbonyl]-3-azetidinyl]-4-piperidinyl]-; 909682-47-9; UNII-9W2B7S6I6Z; 9W2B7S6I6Z; 1-[1-[1-[[6-(Trifluoromethyl)-3-pyridinyl]carbonyl]-3-azetidinyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-(1-(1-(6-(Trifluoromethyl)nicotinoyl)azetidin-3-yl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and impurity profiles. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is likely light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.