Description

4-[5-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Carbonyl)Piperidin-4-Yl)-1,2,4-Oxadiazol-3-Yl]Pyridazine is a sophisticated heterocyclic compound featuring a 1,2,4-oxadiazole core, a piperidine linker, and pyridine/pyridazine termini, which is highly valued for its role as a key pharmaceutical intermediate in modern drug discovery. Its complex molecular architecture, particularly the trifluoromethyl group, is engineered to enhance metabolic stability and binding affinity, making it a critical building block for bioactive molecules. This compound is primarily targeted at research institutions and pharmaceutical R&D teams focused on developing novel therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) disease research.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Protease Inhibitor Development: The oxadiazole and piperidine motifs are common in molecules designed to inhibit specific enzymes, relevant for antiviral and anticancer applications.
• Kinase Inhibitor Synthesis: Employed in the construction of heterocyclic cores for small-molecule kinase inhibitors, a major class of targeted cancer therapies.
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation in cellular assays.

Basic Information

Product Name	4-[5-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Carbonyl)Piperidin-4-Yl)-1,2,4-Oxadiazol-3-Yl]Pyridazine
CAS No.	909675-70-3
Molecular Formula	C19H15F3N6O2
Molecular Weight	416.36 g/mol
Synonyms	4-[5-[1-[[6-(Trifluoromethyl)-3-pyridinyl]carbonyl]-4-piperidinyl]-1,2,4-oxadiazol-3-yl]pyridazine; 4-(5-(1-((6-(Trifluoromethyl)pyridin-3-yl)carbonyl)piperidin-4-yl)-1,2,4-oxadiazol-3-yl)pyridazine; 909675-70-3; 4-(5-(1-(6-(Trifluoromethyl)nicotinoyl)piperidin-4-yl)-1,2,4-oxadiazol-3-yl)pyridazine; 4-[5-(1-{[6-(Trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)-1,2,4-oxadiazol-3-yl]pyridazine; 4-(5-(1-(6-(Trifluoromethyl)pyridine-3-carbonyl)piperidin-4-yl)-1,2,4-oxadiazol-3-yl)pyridazine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent Good Manufacturing Practice (GMP) guidelines where applicable, ensuring traceability and consistency for critical R&D and pre-clinical use. Every batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.