Description

1,6-Naphthyridin-5-Yltrifluoromethanesulfonate is a high-purity triflate ester derivative of the 1,6-naphthyridine heterocycle, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile electrophilic coupling partner, enabling the efficient introduction of the 1,6-naphthyridin-5-yl moiety into complex molecular architectures under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients targeting kinases and other biological receptors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of small molecule drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Research: Used in constructing novel heterocyclic scaffolds for the discovery of new herbicides and fungicides.
• Material Science: Building block for creating organic electronic materials and metal-organic frameworks (MOFs) with specific optoelectronic properties.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed reactions such as Suzuki, Negishi, and Stille couplings to form biaryl structures.
• Ligand Synthesis: Intermediate for the preparation of specialized nitrogen-containing ligands used in catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.

Basic Information

Product Name	1,6-Naphthyridin-5-Yltrifluoromethanesulfonate
CAS No.	909649-09-8
Molecular Formula	C10H5F3N2O3S
Molecular Weight	290.22 g/mol
Synonyms	5-(Trifluoromethanesulfonyloxy)-1,6-naphthyridine; 1,6-Naphthyridin-5-ol Triflate; 1,6-Naphthyridin-5-yl Triflate; 5-Triflyloxy-1,6-naphthyridine; 5-OTf-1,6-Naphthyridine; Trifluoromethanesulfonic Acid 1,6-Naphthyridin-5-yl Ester; 909649-09-8
EINECS	Contact for details

Quality Control

Our 1,6-Naphthyridin-5-Yltrifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to reach ambient temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.