Description

[4-(4-Amino-2-Fluorophenyl)-1-Piperazinyl][4′-Fluoro-4-(Methylsulfonyl)[1,1′-Biphenyl]-2-Yl]-Methanone is a high-purity, advanced pharmaceutical intermediate characterized by its complex biphenyl and piperazine-based molecular structure. This compound is of significant commercial importance for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular interactions. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of proprietary drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• API Synthesis: Used in the research and development phase for constructing complex molecular architectures that are part of potential new APIs.
• Biochemical Research: Employed as a reference standard or a reagent in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Utilized by CDMOs for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the custom synthesis of more complex, fluorinated organic molecules for specialized client projects.

Basic Information

Item	Details
Product Name	[4-(4-Amino-2-Fluorophenyl)-1-Piperazinyl][4′-Fluoro-4-(Methylsulfonyl)[1,1′-Biphenyl]-2-Yl]-Methanone
CAS No.	909418-68-4
Molecular Formula	C24H23F2N3O3S
Molecular Weight	471.52 g/mol
Synonyms	4-(4-Amino-2-fluorophenyl)-1-[4-fluoro-4'-(methylsulfonyl)[1,1'-biphenyl]-2-carbonyl]piperazine; 1-[(4'-Fluoro-4-methylsulfonylbiphenyl-2-yl)carbonyl]-4-(4-amino-2-fluorophenyl)piperazine; Biphenyl-2-yl[4-(4-amino-2-fluorophenyl)piperazin-1-yl]methanone derivative; (4'-Fluoro-4-methylsulfonyl-1,1'-biphenyl-2-yl)-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]methanone; CAS 909418-68-4; 909418-68-4; Advanced Fluorinated Piperazine Intermediate.
EINECS	Contact for details

Quality Control

Our [4-(4-Amino-2-Fluorophenyl)-1-Piperazinyl][4′-Fluoro-4-(Methylsulfonyl)[1,1′-Biphenyl]-2-Yl]-Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.