Description

(Rs)-2-Amino-3-(4-Chloro-3-Hydroxy-5-Isoxazolyl)Propionic Acid is a specialized non-proteinogenic amino acid derivative featuring a substituted isoxazole ring, which serves as a key chiral building block in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting neurological pathways. Researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries need it for constructing complex molecular architectures with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) targets.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators that require specific stereochemistry for optimal activity.
• Biochemical Probe Development: Serves as a precursor for designing and synthesizing molecular probes to study glutamate receptor subtypes and other biological processes.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs and peptidomimetics to enhance metabolic stability, bioavailability, and receptor selectivity.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality in complex synthetic targets.
• Academic & Institutional Research: Utilized in university and R&D laboratory settings for fundamental studies in medicinal chemistry and synthetic methodology.

Basic Information

Product Name	(Rs)-2-Amino-3-(4-Chloro-3-Hydroxy-5-Isoxazolyl)Propionic Acid
CAS No.	909400-43-7
Molecular Formula	C6H6ClN2O4
Molecular Weight	205.58 g/mol
Synonyms	(RS)-2-Amino-3-(4-chloro-3-hydroxy-1,2-oxazol-5-yl)propanoic acid; 2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propanoic acid; 4-Chloro-3-hydroxy-5-isoxazolylalanine; (RS)-4-Chloro-3-hydroxyisoxazole-5-alanine; (RS)-2-Amino-3-(4-chloro-3-hydroxyisoxazol-5-yl)propionic acid; 909400-43-7; (RS)-AHCPA
EINECS	Contact for details

Quality Control

Our production of (Rs)-2-Amino-3-(4-Chloro-3-Hydroxy-5-Isoxazolyl)Propionic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (RS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.