Description

2-Bromo-5-Fluoro-Aniline Hcl is a halogenated aniline derivative that serves as a crucial building block in advanced organic synthesis. Its value lies in its ability to introduce both bromine and fluorine substituents into complex molecular architectures, enabling fine-tuning of electronic and steric properties. This high-purity intermediate is primarily needed by pharmaceutical and agrochemical R&D departments for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the halogen atoms contribute to bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as a starting material for synthesizing complex, halogenated dyes and pigments with specific light-fastness and color properties.
• Cross-Coupling Reactions: An essential substrate for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions to form complex biaryl and amine structures.

Basic Information

Product Name	2-Bromo-5-Fluoro-Aniline Hcl
CAS No.	909274-69-7
Molecular Formula	C6H6BrClFN
Molecular Weight	226.47 g/mol
Synonyms	2-Bromo-5-fluoroaniline hydrochloride; 5-Fluoro-2-bromoaniline HCl; Benzenamine, 2-bromo-5-fluoro-, hydrochloride (1:1); 2-Bromo-5-fluoroaniline monohydrochloride; 2-Bromo-5-fluoro-phenylamine hydrochloride; 909274-69-7; 2-Br-5-F-Aniline·HCl
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluoro-Aniline Hcl is produced and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and commercial synthesis. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.