Description

(R)-Tetrahydro-1H-Oxazolo[3,4-A]Pyrazin-3(5H)-One is a high-value chiral heterocyclic building block of significant interest in advanced pharmaceutical synthesis. Its rigid, fused bicyclic structure containing nitrogen and oxygen atoms makes it a privileged scaffold for medicinal chemistry, particularly in the development of central nervous system (CNS) active agents and enzyme inhibitors. This compound is essential for research and development chemists and process chemists working in pharmaceutical, biotechnology, and fine chemical industries who require high-purity, enantiomerically pure intermediates to accelerate drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to introduce complex stereochemistry.
• Protease Inhibitor Development: Its structure is relevant for designing inhibitors of proteolytic enzymes, applicable in antiviral and anticancer research.
• Ligand and Catalyst Design: Utilized in the development of novel chiral ligands for metal-catalyzed transformations.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein function.

Basic Information

Product Name	(R)-Tetrahydro-1H-Oxazolo[3,4-A]Pyrazin-3(5H)-One
CAS No.	909187-55-9
Molecular Formula	C7H10N2O2
Molecular Weight	154.17 g/mol
Synonyms	(R)-Hexahydro-oxazolo[3,4-a]pyrazin-3-one; (R)-1,4,6,7,8,8a-Hexahydro-oxazolo[3,4-a]pyrazin-3-one; (R)-THOP; (3R)-Tetrahydro-1H,5H-oxazolo[3,4-a]pyrazin-3-one; (R)-Oxazolo[3,4-a]pyrazin-3(5H)-one, tetrahydro-; (R)-enantiomer of Tetrahydro-oxazolopyrazinone
EINECS	Contact for details

Quality Control

Our (R)-Tetrahydro-1H-Oxazolo[3,4-A]Pyrazin-3(5H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.