Description

1-tert-Butyl 2-Methyl 2-(3-Chloropropyl)Pyrrolidine-1,2-Dicarboxylate is a high-purity, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical researchers and process chemists need this intermediate for its versatility in multi-step synthetic routes, enabling the production of high-value, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Research: Used in the development of novel, chiral active ingredients for crop protection products.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or catalysts used in enantioselective transformations.
• Peptidomimetics & Proline Derivatives: Integral for constructing constrained peptide analogs and modified proline structures in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in custom synthesis projects requiring high-purity, specialized intermediates.
• Academic & Industrial R&D: Employed in research laboratories for method development and exploring new synthetic pathways.

Basic Information

Product Name	1-tert-Butyl 2-Methyl 2-(3-Chloropropyl)Pyrrolidine-1,2-Dicarboxylate
CAS No.	909076-34-2
Molecular Formula	C14H24ClNO4
Molecular Weight	305.80 g/mol
Synonyms	1-tert-Butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate; 2-(3-Chloropropyl)-1-(tert-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidine; 1-Boc-2-(methoxycarbonyl)-2-(3-chloropropyl)pyrrolidine; tert-Butyl methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate; N-Boc-2-(3-chloropropyl)proline methyl ester; Protected 2-(3-chloropropyl)proline derivative; 909076-34-2
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 2-Methyl 2-(3-Chloropropyl)Pyrrolidine-1,2-Dicarboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade synthesis. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) are available for every batch, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.