Description

tert-Butyl Spiro[Isochroman-1,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel drug candidates. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of new chemical entities targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and new molecular entities.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Particularly valuable for constructing compounds targeting neurological receptors and pathways, given its spirocyclic and piperidine motifs.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of proprietary compounds for clients.
• Library Synthesis: Used to generate focused chemical libraries for high-throughput screening against novel biological targets.
• Process Chemistry: Serves as an intermediate in the scale-up and process development of potential drug candidates.

Basic Information

Product Name	tert-Butyl Spiro[Isochroman-1,4'-Piperidine]-1'-Carboxylate
CAS No.	909034-76-0
Molecular Formula	C17H23NO3
Molecular Weight	289.37 g/mol
Synonyms	1'-tert-Butoxycarbonylspiro[isochromane-1,4'-piperidine]; tert-Butyl 1-oxa-9-azaspiro[5.5]undecane-9-carboxylate; 9-Boc-1-oxa-9-azaspiro[5.5]undecane; Spiro[isochroman-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,4'-Bicyclospiro[isochroman-piperidine]-1'-tert-butyl carboxylate; BOC-Spiro(Isochroman-1,4'-Piperidine); 909034-76-0
EINECS	Contact for details

Quality Control

Our tert-Butyl Spiro[Isochroman-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.